Table 1.
Baseline characteristics of the 255 patients with inoperable pancreatic cancer
| All cases (n = 255)a | Erythema | P value | ||
|---|---|---|---|---|
| negative (n = 145) | positive (n = 107) | |||
| Age (year) | ||||
| Median (range) | 63 (27–84) | 62 (27–81) | 63 (38–84) | 0.42 |
| Gender—no. (%) | ||||
| Male | 135 (53) | 78 (54) | 55 (51) | 0.71 |
| Female | 120 (47) | 67 (46) | 52 (49) | |
| ECOG performance status score—no. (%) | ||||
| 0 | 59 (23) | 30 (21) | 27 (25) | 0.58 |
| 1 | 159 (62) | 94 (65) | 64 (60) | |
| 2 | 31 (12) | 17 (12) | 14 (13) | |
| 3 | 4 (1.6) | 3 (2) | 1 (1) | |
| 4 | 1 (0.4) | 0 (0) | 1 (1) | |
| NA | 1 (0.4) | 1 (1) | 0 (0) | |
| Clinical stage—no. (%) | ||||
| locally invasive | 78 (31) | 37 (26) | 39 (36) | 0.06 |
| metastasis | 177 (69) | 108 (74) | 68 (64) | |
| Laboratory data at leukapheresis (mean ± S.D.) | ||||
| WBC (/mL) | 5,447 (±2,140) | 5,556 (±2,082) | 5,306 (±2,174) | 0.10 |
| No. of lymphocytes (/mL) | 1,305 (±550) | 1,353 (±595) | 1,245 (±481) | 0.20 |
| Hemoglobin (g/dL) | 11.4 (±1.8) | 11.4 (±1.6) | 11.4 (±1.6) | 0.98 |
| Albumin (g/dL) | 3.9 (±0.5) | 3.9 (±0.6) | 4.0 (±0.4) | 0.24 |
| CRP (mg/dL) | 0.9 (±1.7) | 1.04 (±2.1) | 0.59 (±0.9) | 0.24 |
| WT1 A*2,402/*0,201/*0206 (%) | 207 (81) | 114 (79) | 90 (84) | 0.27 |
| MUC1 (%) | 226 (89) | 129 (89) | 95 (89) | 0.96 |
| OK432 | 184 | 88 | 96 | <0.01* |
| Time to start DC vaccination from diagnosis (months) | ||||
| Median (range) | 4.0 (1–36) | 3.9 (1–36) | 4.2 (1–31) | 0.70 |
| Number of DC vaccines (/leukapheresis) | ||||
| Median (range) | 8 (5–55) | 7 (5–38) | 8 (5–55) | 0.16 |
| Viability of DC vaccines (%) | ||||
| Median (range) | 84.4 (42.0–97.5) | 85.0 (45.3–95.1) | 83.2 (42.0–97.5) | 0.27 |
| Standard therapy combined with DC vaccine—no. (%) | ||||
| Chemotherapy | ||||
| GEM | 135 (53) | 78 (54) | 56 (52) | 0.63 |
| GEM+S-1 | 63 (25) | 38 (26) | 24 (22) | |
| S-1 | 44 (17) | 23 (16) | 21 (20) | |
| others | 13 (5) | 6 (4) | 6 (6) | |
| Radiotherapy | 12 (5) | 4 (3) | 8 (7) | 0.18 |
aincluding no record of erythema (n = 3)
* Statistically significant