Figure 2.
FC features significantly differentiating each of the biotypes: (A) Primary NUD, (B) Mixed NUD/AUD with depression and anxiety biotype, and (C) Mixed AUD/NUD, from HCs in both discovery and replication sets (Wilcoxon rank-sum tests, P < 0.05, Bonferroni corrected). ROIs were color-coded, with node size scaled by its node degree. The edges were color-coded according to the feature effects: red: FC values of the biotype > control, on average; blue: biotype < control, on average, while the edge thickness corresponded to the absolute value of the mean of FC feature difference. The number in the axial view of the brain is the index of ROI, whose axial, coronal, sagittal slice view, and the 3D rendered view can be found in Supplementary Figure S3. Detailed information about the FC features can be found in Supplementary Table S9a. In each panel, shown from left to right are the sagittal, axial, and coronal views of the brain. PSC: primary sensory cortex; VAC: visual association cortex; SVC; secondary visual cortex; IFG: inferior frontal gyrus (pars orbitalis); SMG: supramarginal gyrus; ITG: inferior temporal gyrus.