Figure 2: Protein-Protein Interaction Network For Known Interactors of both FKBP5 and FKBP4.
The venn diagram (top left) collates interactors from the BioGRID protein interaction database for FKBP4 and FKBP5, respectively. TheBioGRID database was accessed 25 September 2022 at 2:32 AM UTC. Results were filtered by evidence type “Interactors with ONLY Physical Evidence (LTP or HTP)” and organism (H. sapiens). Interactors identified only in pre-publication datasets were excluded. Shared interactors (bottom left) were used to generate a PPI network using STRING v11.5 (1–ɑ ≥ 0.5). While interactors were filtered based on methodology detecting physical interaction, not all of these methodologies distinguish between direct interaction versus association through protein complexes. Thus, the interactors shown here may be associated with the FKBPs through larger protein complexes in some cases, but the figure highlights the fact that FKBP51 and FKBP52 have shared interactors as well as a significant number of distinct interactors.