FIG. 1.
Isolation of homologs of S. pombe cdc5+. (A) Alignment of S. pombe cdc5p homologs by using ClustalW1.6 (14, 60). Residues found to be identical or similar to those of Cdc5Hs are highlighted in black or grey, respectively, to emphasize the evolutionary conservation of Cdc5 homologs. Roman numerals signify the beginning of a Myb repeat. Asterisks indicate the positions of the amino acid residues which are classically occupied by tryptophan residues in Myb repeats. Percent identities among the various Cdc5 family members are indicated at the bottom of this panel. (B) Alignment of MLR3 of Cdc5 family members with R3 of human c-, A-, and B-Myb and Drosophila Myb. Alignment was performed by using ClustalW1.6. Identical and similar residues found within the various proteins are highlighted in black and grey, respectively. Residues found to be identical between all proteins are indicated by arrows. Sp, S. pombe; Sc, S. cerevisiae; Hs, H. sapiens; Dm, D. melanogaster. (C) Phylogenetic analysis of Cdc5 and c-Myb family members.