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. 2024 Feb 20;15:1547. doi: 10.1038/s41467-024-45785-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Difference in inhibition zone diameter in millimetres compared to the input P. aeruginosa to a panel of antibiotics for isolates recovered from the a lung, b liver, c blood, d kidney and e spleen. The mean with SD is indicated and n = 3 isolates tested per group f shows a summary of changes in resistance classification according to EUCAST breakpoints. g Minimum Inhibitory Concentration (MIC) of tobramycin and meropenem determined via E-Test for input and in vivo adapted isolates, with fold reduction in MIC shown using a colour scheme (white: no change, dark blue: 10-fold change). Panel of antibiotics included: Piperacillin (PRL), Piperacillin-tazobactam (PTZ), Ticarcillin (TC), Ticarcillin-clavulanic acid (TIM), Cefepime (CPM), Ceftazidime (CAZ), Ceftolozane-tazaobactam (C/T), Imipenem (IMI), Meropenem (MEM), Aztreonam (ATM), Ciprofloxacin (CIP), Levofloxacin (LEV), Amikacin (AK), Tobramycin (TN). Source data are provided as a Source Data file.