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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Trends Genet. 2023 Sep 14;39(12):954–967. doi: 10.1016/j.tig.2023.08.004

Figure 2: WGD requires cellular adaptations.

Figure 2:

Cells which experience unscheduled WGD duplicate their cellular contents (e.g., centrosomes) as well as their genome. The doubling of these structures imposes unique stresses which WGD+ cells must overcome to proliferate. Clear evidence of this is seen with extra centrosomes. If WGD+ cells do not cluster surplus centrosomes during mitosis, the result is a multipolar division with uneven distribution of chromosomes and the production of non-viable daughter cells. To successfully proliferate, WGD+ cells must adapt to cluster their extra centrosomes in order to form a pseudo-bipolar spindle and produce viable progeny.