TABLE 2.
Fungal densities in kidneys of mice treated with various total doses of fluconazole administered in one, two, or four divided doses
| Total fluconazole dose (mg/kg) | Fungal density (mean ± 1 SD log10 CFU/g) for the following schedule of administration:
|
P valuea | ||
|---|---|---|---|---|
| One dose | Two divided dosesb | Four divided dosesc | ||
| 3.5 | 5.79 ± 0.12 | 5.78 ± 0.11 | 5.79 ± 0.12 | 0.68 |
| 4.0 | 5.70 ± 0.11 | 5.69 ± 0.10 | 5.71 ± 0.10 | 0.59 |
| 4.5 | 5.64 ± 0.15 | 5.56 ± 0.27 | 5.62 ± 0.18 | 0.34 |
| 5.0 | 5.48 ± 0.21 | 5.44 ± 0.19 | 5.41 ± 0.11 | 0.46 |
| 5.5 | 5.46 ± 0.14 | 5.25 ± 0.10 | 5.43 ± 0.19 | 0.32 |
a
By analysis of variance. A P value of <0.05 was considered statistically significantly different.
b
The doses were given 12 h apart.
c
The doses were given 6 h apart.