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. 1998 Jul;42(7):1853–1857. doi: 10.1128/aac.42.7.1853

TABLE 4.

Rifamycin resistance of M. tuberculosis recombinant clones

Straina Mutated amino acidb MIC (μg/ml) ofc:
Rifampin Rifabutin Rifapentine KRM-1648
H37Rv None 0.25 ≤0.015 0.031 ≤0.015
H37Rv-pLN-2 None 0.25 ≤0.015 0.031 ≤0.015
H37Rv-pLN-sig None 0.25 ≤0.015 ≤0.031 ≤0.015
H37Rv-pAV Val 516 32 ≤0.015 16 ≤0.015
H37Rv-pHT Tyr 526 64 16 16 8
H37Rv-pSL Leu 531 >64 16 >64 8
H37Rv-Rif-r Leu 531 >64 16 >64 8
a

H37Rv, M. tuberculosis H37Rv (ATCC 27294); H37Rv-pLN-2, M. tuberculosis H37Rv clone containing plasmid pLN-2 with wild-type rpoB; H37Rv-pLN-sig, M. tuberculosis H37Rv clone containing pLN-sig with signature nucleotides in rpoB; H37Rv-pAV, M. tuberculosis H37Rv clone containing plasmid pAV with Val 516 mutant allele in rpoB; H37Rv-pHT, M. tuberculosis H37Rv clone containing plasmid pHT with Tyr 526 mutant allele in rpoB; H37Rv-pSL, M. tuberculosis H37Rv clone containing plasmid pSL with Leu 531 mutant allele in rpoB; H37Rv-Rif-r, M. tuberculosis H37Rv (ATCC 35838). 

b

Amino acid numbering corresponds to that of the E. coli RNA polymerase β-subunit. 

c

MICs determined by the BACTEC radiometric method.