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. Author manuscript; available in PMC: 2023 Oct 5.
Published in final edited form as: Cell Rep. 2023 Jul 27;42(8):112901. doi: 10.1016/j.celrep.2023.112901

Figure 4. Fmr1 KO mice exhibit altered synaptic function and spine density in DLS striatum.

Figure 4.

(A) mEPSCs from neighboring Drd1- and Drd2-SPNs in WT control (left) or Fmr1 KO (right) mice. Scale bar, 5 pA, 500 ms (top) or 5 pA, 50 ms (bottom).

(B) Summary of mEPSC amplitude at Drd1-and Drd2-SPNs in control and Fmr1 KO mice.

(C–G) (C) Summary of mEPSC frequency at Drd1- and Drd2-SPNs in control and Fmr1 KO mice. Fmr1 KO exhibit increased mEPSC frequency at Drd1-SPNs. Cumulative frequency plot of mEPSC amplitude (D) or ISI (E) recorded from Drd1- or Drd2-SPNs DLS of Fmr1 KO mice. High-magnification images (left) and quantification (right) of Drd1-SPNs (F) and Drd2-SPNs (G) spiny dendrites of WT and Fmr1 KO mice (scale bar, 5 μm). *p < 0.05. Error bars are ±SEM. See Table S1 for full statistical information.