Retraction Note: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis

Retraction Note: Alz Res Ther 13, 37 (2021)

https://doi.org/10.1186/s13195-021-00769-9

The Editors-in-Chief have retracted this article at the authors' request. After publication, concerns were raised regarding a number of cases of image overlap within the Figures, which the authors addressed by a Correction [1]. However, subsequent concerns have been raised about further image similarities within the article, as well as with previous studies. Specifically:

• Fig. 3b 5xFAD + Veh CAI 12-month-old group image appears highly similar to an image representing the same group in [2].

• In Fig. 3B, 5xFAD + SCLP Cortex and Entorhinal cortex images appear to originate from the same sample.

• In Fig. 3E, the beta-tubulin blots presented for the cortex 6- and 12-month-old groups appear highly similar; the beta-tubulin blot image for hippocampus in the 6-month-old group appears highly similar to that representing beta-tubulin in the 12-month-old group in Figs. 5F and 7A.

• The updated Fig. 4G 5xFAD Primary 6-month-old group image appears to overlap with Fig. 4I 5xFAD Secondary 12-month-old group.

• The top beta-tubulin blot in Fig. 6F appears highly similar to the beta-tubulin (hippocampus) blot in Fig. 7A.

• The blots in Fig. S2I appear highly similar to those in Fig. 3D of [3, now retracted].

• Fig. S5A appears highly similar to the Merged 5xFAR + SLCP (2d) image in Fig. 1B of [3, now retracted].

Despite internal data validation, the authors no longer have sufficient confidence in the findings of this study.

All authors agree to this retraction.