Table 2.
HR for CVD and all-cause mortality associated with different combination of cardiometabolic risk factors
| No. of participants | CVD | Stroke | CHD | All-cause mortality | |||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | HR (95%CI) | Cases | HR (95%CI) | Cases | HR (95%CI) | Cases | HR (95%CI) | ||
| The number of cardiometabolic risk factors | |||||||||
| None | 12,153 | 282 | Reference | 170 | Reference | 78 | Reference | 349 | Reference |
| One | 8436 | 533 | 1.59 (1.37–1.85) | 328 | 1.65 (1.36–2.00) | 160 | 1.63 (1.23–2.16) | 593 | 1.38 (1.20–1.58) |
| Two | 1870 | 157 | 1.82 (1.49–2.24) | 88 | 1.67 (1.27–2.18) | 57 | 2.30 (1.61–3.30) | 164 | 1.66 (1.37–2.02) |
| Three | 137 | 19 | 2.97 (1.85–4.75) | 10 | 2.51 (1.31–4.78) | 8 | 3.92 (1.86–8.23) | 20 | 2.97 (1.88–4.69) |
| The type of cardiometabolic risk factors | |||||||||
| None | 12,153 | 282 | Reference | 170 | Reference | 78 | Reference | 349 | Reference |
| Diabetes only | 830 | 36 | 1.31 (0.93–1.86) | 20 | 1.22 (0.76–1.94) | 14 | 1.83 (1.03–3.24) | 58 | 1.79 (1.36–2.37) |
| High LDL-C only | 632 | 15 | 0.82 (0.49–1.38) | 8 | 0.70 (0.34–1.42) | 7 | 1.52 (0.70–3.30) | 16 | 0.76 (0.46–1.25) |
| Hypertension only | 6974 | 482 | 1.68 (1.44–1.96) | 300 | 1.78 (1.46–2.17) | 139 | 1.62 (1.21–2.16) | 519 | 1.37 (1.19–1.58) |
| Diabetes + High LDL-C | 73 | 2 | 0.77 (0.19–3.08) | 0 | - | 1 | 1.51 (0.21–10.92) | 4 | 1.28 (0.48–3.43) |
| Diabetes + Hypertension | 1236 | 116 | 2.06 (1.64–2.58) | 64 | 1.90 (1.40–2.56) | 41 | 2.41 (1.62–3.59) | 121 | 1.92 (1.55–2.39) |
| High LDL-C + Hypertension | 561 | 39 | 1.45 (1.03–2.05) | 24 | 1.42 (0.92–2.20) | 15 | 2.06 (1.17–3.63) | 39 | 1.16 (0.83–1.62) |
| Diabetes + High LDL-C + hypertension | 137 | 19 | 3.02 (1.88–4.83) | 10 | 2.56 (1.34–4.89) | 8 | 3.96 (1.89–8.33) | 20 | 3.02 (1.92–4.77) |
CVD cardiovascular disease, CI confidential interval, CHD coronary heart disease, HR hazard ratio, LDL-C low-density lipoprotein cholesterol