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. 1988 Jan;72(1):2–4. doi: 10.1136/bjo.72.1.2

Increased procollagenase activating angiogenic factor in the vitreous humour of oxygen treated kittens.

C M Taylor 1, J B Weiss 1, B McLaughlin 1, R D Kissun 1, A Garner 1
PMCID: PMC1041356  PMID: 2449242

Abstract

Previous studies have demonstrated an increase in a low molecular weight angiogenic factor (ESAF) present in the retinae of kittens with oxygen induced retinopathy. The present paper describes differences in the quantity of ESAF extracted from the vitreous humour of control and oxygen treated animals and proposes a mechanism for the induction of intravitreal neovascularisation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASHTON N. Retinal vascularization in health and disease: Proctor Award Lecture of the Association for Research in Ophthalmology. Am J Ophthalmol. 1957 Oct;44(4 Pt 2):7–17. doi: 10.1016/0002-9394(57)90426-9. [DOI] [PubMed] [Google Scholar]
  2. ASHTON N., WARD B., SERPELL G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol. 1954 Jul;38(7):397–432. doi: 10.1136/bjo.38.7.397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brem S., Cotran R., Folkman J. Tumor angiogenesis: a quantitative method for histologic grading. J Natl Cancer Inst. 1972 Feb;48(2):347–356. [PubMed] [Google Scholar]
  4. Elstow S. F., Schor A. M., Weiss J. B. Bovine retinal angiogenesis factor is a small molecule (molecular mass less than 600). Invest Ophthalmol Vis Sci. 1985 Jan;26(1):74–79. [PubMed] [Google Scholar]
  5. Folkman J. Tumor angiogenesis. Adv Cancer Res. 1974;19(0):331–358. doi: 10.1016/s0065-230x(08)60058-5. [DOI] [PubMed] [Google Scholar]
  6. Glaser B. M., D'Amore P. A., Michels R. G. The effect of human intraocular fluid on vascular endothelial cell migration. Ophthalmology. 1981 Sep;88(9):986–991. doi: 10.1016/s0161-6420(81)80016-4. [DOI] [PubMed] [Google Scholar]
  7. Goodson W. H., 3rd, Andrews W. S., Thakral K. K., Hunt T. K. Wound oxygen tension of large vs small wounds in man. Surg Forum. 1979;30:92–95. [PubMed] [Google Scholar]
  8. Gospodarowicz D., Thakral K. K. Production a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum. Proc Natl Acad Sci U S A. 1978 Feb;75(2):847–851. doi: 10.1073/pnas.75.2.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hill C. R., Kissun R. D., Weiss J. B., Garner A. Angiogenic factor in vitreous from diabetic retinopathy. Experientia. 1983 Jun 15;39(6):583–585. doi: 10.1007/BF01971107. [DOI] [PubMed] [Google Scholar]
  10. Jacobson B., Dorfman T., Basu P. K., Hasany S. M. Inhibition of vascular endothelial cell growth and trypsin activity by vitreous. Exp Eye Res. 1985 Nov;41(5):581–595. doi: 10.1016/0014-4835(85)90031-4. [DOI] [PubMed] [Google Scholar]
  11. Kissun R. D., Garner A. Vasoformative properties of normal and hypoxic retinal tissue. Br J Ophthalmol. 1977 Jun;61(6):394–398. doi: 10.1136/bjo.61.6.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kissun R. D., Hill C. R., Garner A., Phillips P., Kumar S., Weiss J. B. A low-molecular-weight angiogenic factor in cat retina. Br J Ophthalmol. 1982 Mar;66(3):165–169. doi: 10.1136/bjo.66.3.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Knighton D. R., Silver I. A., Hunt T. K. Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration. Surgery. 1981 Aug;90(2):262–270. [PubMed] [Google Scholar]
  14. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  15. Taylor C. M., Weiss J. B., Kissun R. D., Garner A. Effect of oxygen tension on the quantities of procollagenase-activating angiogenic factor present in the developing kitten retina. Br J Ophthalmol. 1986 Mar;70(3):162–165. doi: 10.1136/bjo.70.3.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Taylor C. M., Weiss J. B. Partial purification of a 5.7K glycoprotein from bovine vitreous which inhibits both angiogenesis and collagenase activity. Biochem Biophys Res Commun. 1985 Dec 31;133(3):911–916. doi: 10.1016/0006-291x(85)91222-7. [DOI] [PubMed] [Google Scholar]
  17. WISE G. N. Retinal neovascularization. Trans Am Ophthalmol Soc. 1956;54:729–826. [PMC free article] [PubMed] [Google Scholar]
  18. Weiss J. B., Hill C. R., Davis R. J., McLaughlin B., Sedowofia K. A., Brown R. A. Activation of a procollagenase by low-molecular-weight angiogenesis factor. Biosci Rep. 1983 Feb;3(2):171–177. doi: 10.1007/BF01121948. [DOI] [PubMed] [Google Scholar]

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