Table 1.
Prognostic value of polyploid/senescent cancer cells.
| Author | Date | Cancer Type | No of Patients | Outcome |
|---|---|---|---|---|
| Wang et al. [22] | 2012 | Non-small-cell lung cancer | 18 | Patients expressing markers of senescence following neoadjuvant therapy had a significantly worse prognosis than patients who did not express these markers. |
| Qu et al. [37] | 2013 | Glioma | 76 | The number of PGCCs increased with the grade of tumors. |
| Lv et al. [42] | 2014 | Serous ovarian cancer | 80 | The presence of PGCCs in the primary tumor correlated with metastasis. |
| Fei et al. [40] | 2015 | Primary breast tumors, lymph node metastases, and benign tissue | 167 | The number of PGCCs was the highest in patients with lymph node metastases. |
| Gerashchenko et al. [41] | 2016 | Breast cancer | 30 | Tumors with a higher proportion of PGCCs showed a poorer response to neoadjuvant chemotherapy. |
| Zhang et al. [43] | 2017 | Colon cancer | 169 | The presence of PGCCs with budding increased as tumors became more dedifferentiated. |
| Liu et al. [38] | 2018 | Anorectal melanoma | 47 | The proportion of PGCCs increased with tumor size. |
| Alharbi et al. [46] | 2018 | Prostate cancer | 30 | Pleomorphic giant cells were present in all 30 patients with a rare variant of prostate cancer. |
| Mannan et al. [45] | 2020 | Prostate cancer | 5 | Multiple cells with highly irregular polylobulated nuclei or multiple pleomorphic nuclei were present in autopsy samples of patients who had failed multiple lines of therapy. |
| Liu et al. [39] | 2021 | Laryngeal cancer | 102 | High numbers of PGCCs correlated with poor prognosis. |
| Trabzonlu et al. [36] | 2023 | Prostate cancer | 209 | PGCCs were significant prognostic factors for metastasis in patients who underwent radical prostatectomy with curative intent to treat their presumed localized cancer. |