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. 2023 Jun 7;14:1114780. doi: 10.3389/fimmu.2023.1114780

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Copyright © 2023 Morina, Jones, Oguz, Kaplan, Gangaplara, Fitzhugh, Kanakry, Shevach and Buszko

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Administration of hIL-2 does not induce Foxp3 expression in T_conv during xeno-GVHD. (A) NSG mice engrafted with hPBMCs (10 x10⁶) were injected with either hIL-2 (1 x 10⁵ IU, n=5) or PBS (n=6) on day 11, 12, and 13. CD4⁺ T cells from a representative mouse spleen on day 14 and summary data on CD25, Foxp3 and Helios expression from all recipients are shown. (B) IL-2, IFNγ, and granzyme B production by cells in panel A were determined by flow cytometry and summary IL-2 data from all recipients is shown. Plots are representative of one of two independent experiments.***p<0.0005, ****p<0.0001, two-way ANOVA with Tukey’s multiple comparisons test.