Table 2.
Model details and validation results for the prediction of cisplatin response using CisSig in GDSC dataset.
| Input | Output | Method | Included data | Metric | Value |
|---|---|---|---|---|---|
| CisSig Score | IC50 (continuous) | Simple Linear Regression | All | Corr. Coef. | 0.51 |
| CisSig Score | IC50 (continuous) | Simple Linear Regression | Quintiles | Corr. Coef. | 0.74 |
| All gene expression | IC50 (continuous) | Elastic Net Linear Regression | All | Corr. Coef. | 0.63 |
| All gene expression | IC50 (continuous) | Elastic Net Linear Regression | Quintiles | Corr. Coef. | 0.79 |
| All gene expression | IC50 (continuous) | L1 Linear Regression | All | Corr. Coef. | 0.63 |
| All gene expression | IC50 (continuous) | L1 Linear Regression | Quintiles | Corr. Coef. | 0.79 |
| All gene expression | IC50 (continuous) | L2 Linear Regression | All | Corr. Coef. | 0.63 |
| All gene expression | IC50 (continuous) | L2 Linear Regression | Quintiles | Corr. Coef. | 0.81 |
| All gene expression | IC50 (binary) | Simple Logistic Regression | All | AUC | 0.79 |
| All gene expression | IC50 (binary) | Simple Logistic Regression | Quintiles | AUC | 0.90 |
| All gene expression | IC50 (binary) | Elastic Net Logistic Regression | All | AUC | 0.82 |
| All gene expression | IC50 (binary) | Elastic Net Logistic Regression | Quintiles | AUC | 0.94 |
| All gene expression | IC50 (binary) | L1 Logistic Regression | All | AUC | 0.82 |
| All gene expression | IC50 (binary) | L1 Logistic Regression | Quintiles | AUC | 0.94 |
| All gene expression | IC50 (binary) | L2 Logistic Regression | All | AUC | 0.81 |
| All gene expression | IC50 (binary) | L2 Logistic Regression | Quintiles | AUC | 0.95 |
| All gene expression | IC50 (binary) | SVM (linear kernel) | All | AUC | 0.82 |
| All gene expression | IC50 (binary) | SVM (linear kernel) | Quintiles | AUC | 0.93 |
| All gene expression | IC50 (binary) | SVM (polynomial kernel) | All | AUC | 0.78 |
| All gene expression | IC50 (binary) | SVM (polynomial kernel) | Quintiles | AUC | 0.94 |
| All gene expression | IC50 (binary) | Random Forest | All | AUC | 0.81 |
| All gene expression | IC50 (binary) | Random Forest | Quintiles | AUC | 0.91 |