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. 1992 Apr;51(4):481–484. doi: 10.1136/ard.51.4.481

Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.

M L Selley 1, D J Bourne 1, M R Bartlett 1, K E Tymms 1, A S Brook 1, A M Duffield 1, N G Ardlie 1
PMCID: PMC1004696  PMID: 1586244

Abstract

(E)-4-Hydroxy-2-nonenal (HNE), a cytotoxic propagation product of lipid peroxidation, is present in the synovial fluid (0.54 (0.19) mumol/l; mean (SE), n = 9) and plasma (0.34 (0.09) mumol/l, n = 9) of patients with rheumatoid arthritis. This compound was also found in the synovial fluid (0.24 (0.19) mumol/l, n = 9) and plasma (0.09 (0.03) mumol/l, n = 9) of patients with osteoarthritis. The concentration of HNE in the plasma of patients with rheumatoid arthritis was significantly greater than in patients with osteoarthritis.

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Selected References

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