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Summary of effects of LRH-1 small molecules.
| RJW100 | 6N | 10CA | 6N-10CA | |
|---|---|---|---|---|
| Site of contact | deep (indirect) | deep (direct) | deep (indirect) mouth (direct) |
deep (direct) mouth (direct) |
| Cholesterol/lipid synthesis (gene expression) | n/a | − − | no change | + |
| Cyp7a1 expression | n/a | + + | − | + + |
| Shp expression | n/a | + | − | + + |
| LXXLL Binding | n/a | + | + | + + |
| Coregulator Signaling | +/− | + +/− | + + | + + |
| PL-like allostery | − − | − | + + | + + |
